Despite Arsene Wenger's insistence he would stay until the end of the season, Alexis Sanchez has ditched Arsenal and headed north for greener pastures.
The writing had been on the wall for Arsenal and Wenger long before Manchester United broke the news on Monday, with mumblings of the Chilean's discontent starting as far back as December 2016.
Back then, when contract negotiations were reportedly starting to become protracted, Wenger was defiant in the face of speculation, adamant both Sanchez and Mesut Ozil were not going to be allowed to leave before the expiration of their contracts in June 2018. He was the boss and he was going to have his way.
But, fast forward 13 months and the Frenchman has been forced to watch helplessly as his star man - surely frustrated with Arsenal's inability to challenge in Europe or the Premier League - secures a move to a side able to offer such demands. Yet again.
Sanchez is by no means the first big star to escape Wenger's clutches, with supporters starting to become accustomed to seeing their most cherished and adored depart at their peak.
We examine the other major players to leave Arsenal since 'The Invincibles' won the 2003-04 Premier League title and how they fared thereafter.
Patrick Vieira (August 2005 - Juventus, £13.75m)
Their captain, leader, midfield lynchpin and chief battler. Although there were aspects to Vieira's game that were perhaps those of a bygone era - such as his willingness for a scrap with Roy Keane - few can argue that the Frenchman was not missed after his departure.
Wenger later claimed that he sold Vieira in order to get the best out of a young Cesc Fabregas, though the French World Cup winner only went on to enjoy more and more success.
Granted, the Serie A title he won in his only campaign with Juventus was taken from the club during the Calciopoli scandal, but he claimed four legitimate titles with Inter before ending his playing days at City. Arsenal, meanwhile, have won just three trophies (all in the FA Cup) since Vieira left.
Thierry Henry (June 2007 - Barcelona, £16.1m)
When Henry left Arsenal for Barcelona in 2007, his main reason for leaving was the uncertainty surrounding Wenger's future. Little did he know that, 10 years on, the 68-year-old would still be clinging on in what often seems like a cruel joke at the expense of exasperated Arsenal fans.
He reportedly cried upon his departure, though he was soon able to console himself with a clutch on trophies, as he played a vital role in Barca's historic 2008-09 treble and won a total of seven titles in three years with the Catalan giants.
Henry did later enjoy a romantic return to Arsenal for a short loan spell in 2012 halfway through his four-year stint at New York Red Bulls, but supporters would surely have preferred him to just stay put in the first place.
Cesc Fabregas (August 2011 - Barcelona, £35m)
The main beneficiary of Vieira's exit, Fabregas quickly established himself as one of the Premier League's finest midfielders, though the combination of his talent and Barca roots was always likely to be a deadly cocktail in Arsenal's hopes of keeping him long term.
And, to the surprise of no one, Fabregas returned home to Barca in August 2011, scoring 15 and setting up another 20 in all competitions in his first season as the club claimed four trophies.
The rest of his Barca stay was never quite what it should have been, however, as regular mumblings suggested all was not well behind the scenes and he ultimately returned to London three years after he left, incurring the wrath of Gunners fans by joining Chelsea, where he remains.
60 - Since Alexis Sanchez joined Arsenal in 2014, only Harry Kane (96), Sergio Aguero (86) and Romelu Lukaku (64) have scored more Premier League goals than the Chilean. Devil. #Alexis7 pic.twitter.com/MxpJCK5UAs— OptaJoe (@OptaJoe) January 22, 2018
Samir Nasri (August 2011 - Manchester City, £25m)
Nasri had developed into one of the Premier League's finest playmakers by the end of his time at Arsenal, his progress resulting in a transfer tug-of-war between the two Manchester clubs following the conclusion of the 2010-11 season.
City won that battle and, while Nasri seemed to continue his development for a couple of years, he could perhaps be accused of never quite reaching his full potential, even if he did win two Premier League titles.
After a disappointing final two seasons at City, he was sent out on loan upon Pep Guardiola's arrival and impressed at Sevilla, but he did not convince them enough to secure a permanent deal or a move to another European heavyweight. He settled for a switch to Turkey's Antalyaspor and is reportedly angling for another transfer in January.
Robin van Persie (August 2012 - Manchester United, £24m)
The saga that surrounded Van Persie's departure to United bears a strong resemblence to that of Sanchez - frustration with Arsenal's failure to challenge for major titles ultimately led to Van Persie stalling on a contract renewal, before eventually telling the club he simply was not going to sign a new deal.
That forced Arsenal into the sale and United were always the frontrunners, with the Dutchman's 26 goals inspiring United to Premier League glory in his first campaign, which was also Alex Ferguson's last in charge.
Although he scored another 22 league goals over the next two seasons, injuries had a noticeable impact on his performance levels and he was allowed to leave for Fenerbahce in 2015.
|Barca clash a chance for Chelsea ´to do things right´, proclaims Rudiger|
|Lucas claims Tottenham can win Champions League|
|Barcelona tie will not decide Conte´s Chelsea future, says Deco|
|Lewandowski won´t be distracted by Real Madrid rumours|
|Man Utd must not underestimate Sevilla - Navas|
|Iniesta will not be made welcome at Stamford Bridge, warns Azpilicueta|
|Ballack sees ´a big difference´ between Bundesliga and Premier League|
|Betis boss would have preferred to face Madrid´s BBC|
|Chelsea v Barcelona: Messi´s blues against the Blues|
|James leaving Madrid was the best thing, says father|
|He´s looking good – Zidane thrilled with Ronaldo|
|It needs to take 30 seconds – Matic wants quicker VAR|
|Gattuso: My job is to be the players´ nightmare until season´s end|
|I wasn´t good enough – Guardiola reveals Wigan rejection|
|Brazilian derby between Vitoria and Bahia abandoned after red-card frenzy|
|It was crazy, but I like that - Zidane revels in eight-goal Betis thriller|
|Asensio credits Zidane for Madrid´s thrilling Betis comeback|
|Zidane hopeful over Marcelo hamstring injury|
|Bonaventura claims Milan can catch Inter|
|Bravo for Claudio! Guardiola to pick keeper at Wembley|
|Mourinho hoping for reinforcements at Sevilla|
|Real Madrid become first side to score 6,000 goals in LaLiga|
|Real Betis 3 Real Madrid 5: Asensio at the double in LaLiga classic|
|AC Milan 1 Sampdoria 0: Bonaventura makes it 10 unbeaten for Rossoneri|
|Schurrle excited to finally link up with Reus and Gotze|
|Real Madrid defender Marcelo suffers hamstring injury|
|Costa fumes referees ´want to give me a card´, but Simeone plays down penalty row|
|Stoger makes Dortmund history with Gladbach win|
|Championship Review: Leeds fight back for point, Norwich & Ipswich share derby spoils|
|Borussia Monchengladbach 0 Borussia Dortmund 1: Burki unbeatable as Reus returns to haunt Foals|
|FA Cup ´magic´ no surprise to Pochettino after Rochdale thriller|
|Rochdale hero Davies: This is every kid´s dream|
|Atletico Madrid will not stop in pursuit of Barcelona, promises Gameiro|
|´Wrong image´ to blame for VAR confusion in Manchester United´s FA Cup win|
|Rochdale 2 Tottenham 2: Davies denies Kane in FA Cup classic|
|Atletico Madrid 2 Athletic Bilbao 0: Gameiro and Costa settle cagey clash|
|Napoli set club record with another Serie A win|
|Napoli 1 SPAL 0: Allan sends hosts top of Serie A again|
|Allegri allays Higuain injury fears|
|Allegri convinced Juve can get past Spurs|
|Everton fear ´long-term´ injury for Mangala|
|If it isn´t Madrid, it´s Paris - Hazard tires of speculation|
|Torino 0 Juventus 1: Champions win derby but lose Higuain|
|Neymar exit made Barcelona stronger - Ter Stegen|
|Injured Higuain forced off against Torino|
|Jesus confident of returning strong after knee injury|
|We had to change hotels – Ovrebo recalls fury after 2009 Chelsea-Barcelona semi-final|
|Spalletti: Inter board will decide my future|
|Fabregas still wary of timeless Iniesta|
|Liverpool´s 30-goal hero Salah: There´s more to come|
|Valverde: Coutinho dropped for the good of Barcelona|
|Ronaldo better than Neymar? No says Xavi|
|Real Madrid hurt you with nothing – Xavi says PSG loss an injustice|
|Conte: Chelsea need perfect game to stop Messi and Barcelona|
|Inter in a fragile moment, says Spalletti|
|Booed Emery praises PSG´s mental strength|
|Cavani hails ´good reaction´ as PSG bounce back in style|
|Mourinho wants referees to have final say on VAR|
|Genoa 2 Inter 0: Pandev piles misery on old employers|
|Manchester United to host Brighton in FA Cup quarter-finals|
|Mata ´still up for VAR´ despite disallowed goal at Huddersfield|
|Valverde: Barcelona had to suffer at Eibar|
|Championship Review: Fulham end Villa run, Cardiff pounce|
|Huddersfield Town 0 Manchester United 2: Lukaku sends visitors through after VAR controversy|
|Bayern Munich boss Heynckes hails game-changing Muller|
|Locadia benefiting from ´competitive´ Brighton - Hughton|
|Baby on board? Alba dedicates Barca goal to girlfriend|
|West Brom future ´not a decision for me´, says Pardew|
|Paris Saint-Germain 5 Strasbourg 2: Cavani at the double in bounce-back win|
|Bar-celona! Messi posts unwanted record|
|Barca go 31 LaLiga games unbeaten to tie club record|
|Mourinho: I don´t know and I don´t care when Pogba returns|
|Brighton and Hove Albion 3 Coventry City 1: Locadia, Ulloa lead Seagulls to quarter-finals|
|EIbar 0 Barcelona 2: Suarez and Alba seal points as Orellana sees red|
|West Brom 1 Southampton 2: Rondon stunner in vain as Baggies drop out|
|Wolfsburg 1 Bayern Munich 2: Lewandowski spot-on after Robben´s penalty miss|
|I hope Cutrone finds a beautiful girlfriend so he can rest and make love - Gattuso|
|Allegri denies Champions League ´obsession´ ahead of Turin derby|
|Barry, Evans start for West Brom after training camp incident|
|Sheffield Wednesday 0 Swansea City 0: Carvalhal settles for replay on Hillsborough return|
|Management ´tiring´ but Zidane not ready to leave Madrid just yet|
|Thiago back for Bayern as Heynckes rests stars for Besiktas|
|Simeone urges Atletico fans to get behind Griezmann|
|Robben amazed by Guardiola´s impact at Manchester City|
|Pogba out of Man Utd´s Huddersfield trip with illness|
|A-League Review: Perth ´Panenka´ punished, 10-man Adelaide rescue late draw|
|Robben targets two more years at the ´highest level´|
|Rashford and Herrera ´have a chance´ of making Sevilla trip|
|Emery defends PSG star Neymar after Madrid display|
|Mahrez saga now over, says Leicester boss Puel|
|Alonso to return for Barca clash but Bakayoko set to miss first leg – Conte|
|Mourinho: Manchester United will sign a midfielder|